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CDK12 inhibitor 2
CAS No. ——
CDK12 inhibitor 2( —— )
Catalog No. M16942 CAS No. ——
CDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9.
CDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCDK12 inhibitor 2
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NoteResearch use only, not for human use.
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Brief DescriptionCDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9.
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DescriptionCDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9; also potently inhibitor CDK13 with IC50 of 10 nM; inhibits the phosphorylation of Ser2 in the C-terminal domain (CTD) of RNA polymerase II in SK-BR-3 cells at low submicromolar concentrations (iC50=0.195 uM), inhibits the growth of SK-BR-3 cells with IC50 of 0.8 uM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight532.648
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Molecular FormulaC32H32N6O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3-benzyl-1-((1r,4r)-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ito M, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00683.
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