CDK12 inhibitor 2
CAS No.
CDK12 inhibitor 2 ( —— )
Catalog No. M16942 CAS No.
CDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCDK12 inhibitor 2
-
NoteResearch use only, not for human use.
-
Brief DescriptionCDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9.
-
DescriptionCDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9; also potently inhibitor CDK13 with IC50 of 10 nM; inhibits the phosphorylation of Ser2 in the C-terminal domain (CTD) of RNA polymerase II in SK-BR-3 cells at low submicromolar concentrations (iC50=0.195 uM), inhibits the growth of SK-BR-3 cells with IC50 of 0.8 uM.
-
Synonyms——
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number--
-
Formula Weight532.65
-
Molecular FormulaC32H32N6O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name3-benzyl-1-((1r,4r)-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)urea
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ito M, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00683.
molnova catalog
related products
-
BAY 1251152
BAY 1251152 is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM.
-
FN-1501
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).
-
THZ-1 hydrochloride
THZ-1 hydrochloride is a potent, selective, covalent CDK7 inhibitor with IC50 of 3.2 nM; also weakly inhibits CDK12 with IC50 of 250 nM.